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He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. If you want to read more about rebiopsying embryos, check out my archives for embryo rebiopsy. I think whats missing is the success rates for transfers of non PGS tested embryos. Normal Embryo Success Rate: RMA Research Study (The embryo split!) It took me 3 fresh + 3 frozen but I finally did get my baby. MENTS THROUGHOUT MENTS I"ve not had a chance to actually talk with my RE yet, hopefully I will tomorrow after I go back for monitoring. Note that this paper is still preprint as of Nov 2021. This is my second failure of a PGS tested embryo, and the first on this immune suppressing protocol. I guess this probably qualifies me as a poor responder which obviously doesn't feel good after all the other issues we've had. For the autoimmune stuff above I was tested by Alexander Kofinas. I just wanted to know if anyone had a similar experience and if you can share the things you did differently with your second transfer and had success? We did do some things differently, however my RE did these things more to appease me because he knew how frustrated I was than because he thought they were medically necessary. I can totally see not doing it though. And I can't say thats the sole reason this one stuck, but it is the one thing we did differently, and here I am. Every positive thing helps! I have to say that I'm not 100% sure I needed any of the extra things we did- but I wanted to try whatever I could and these things couldn't hurt. Weve discussed euploid embryos, mosaic embryos, so what about aneuploid embryos? There are many potential causes of an . PGS enhances the success of IVF but not in all cases; the success rates vary by age. Obviously this is not an ideal situation but sometimes this happens. I am 42. Saw a heartbeat at 6 and 8 weeks then nothing at week 10. An embryo with more or fewer than 23 chromosome pairs may be at increased risk of miscarriage or certain genetic disorders. My doctor is recommending a Receptiva test to uncover any other reasons why the pregnancies won't last. But wait! We strive to provide you with a high quality community experience. thank you so much! How does anyone not go completely crazy through this whole process???? Best of luck on your next FET! Unfortunately my 2nd retrieval wasnt as positive as yours - I didnt have any make it to blast So Im struggling with my next steps (as Im older) and whether a 3rd retrieval makes sense given the odds. Your experience gives me hope so thank you for sharing , - Estradiol patches and to apply 4 of them and change them every 2 days, - progesterone 200mg suppository morning and evening. ERA testing: Hi lovely people , as per - Fertility Network UK MENTS We were devastated after our first pgs transfer ended in a chemical, and unfortunately we went on to have one more before finding success. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. I did acupuncture that cycle. And since then Ive had medical issues that havent allowed me to try again until last month. My first FET was a day 6 5AA euploid embryo. My husband and I started trying to get pregnant about a year ago (we're both 35). Note: I'm also doing a pregnancy loss blood panel to investigate clotting, and am looking into autoimmune causes as well. My second was ectopic, my third was a failure and Im about 7.5 weeks pregnant from my 4th (). Turns out I was 24 hours prereceptive and Im convinced the ERA and extra day of progesterone is what did it. I am so frustrated and emotional, I am not having any pregnancy symptoms, beside some minor vaginal cramping and sore breast. It was an incredibly long and intense process but looking back I did not have time on my side for my eggs so it was the right decision for us. My previous cycle where I started the prep medications (minivelle and ganirelix) was shorter (23 days) than my typical cycle (25-28) days. I took the year off to just work on myself and be in a better mental state. After each failed transfer, my RE did a lot of additional testing including a Yale EFT biopsy for receptivity and a clotting test to see if I needed lovenox and/or baby aspirin. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. END MENTS. Note that this post is current as of July 2022. 2nd was an FET that was a chemical, likely due to an embryo issue, even though it was graded highest. For these groups, about 50% of biopsies had noeuploidembryos. Ive done 4 transfers now with PGS tested embryos - the first failed and the last 3 resulted in chemical pregnancies. Note that this is per transfer data. I ended up taking Lovenox and Prednisone and doing an endometrial scratch biopsy and ERA. Can you tell me the success rate? Preimplantation genetic testing (PGT) is the process of testing embryos created during in vitro fertilization (IVF) to determine the presence of genetic abnormalities that can lead to pregnancy complications, birth defects, congenital disease and/or miscarriage. Ill also update this blog to include that info. Has anyone experienced a failure or chemical pregnancy when transferring a PGS normal embryo *AND* being on an autoimmune protocol? And demand that my lining be over 8 before I allow another transfer to occur? Thanks so much for sharing! Terms are highlighted every 3rd time to avoid repetition. I had biopsies after a polyp removal which showed residual B cells (even after 3 rounds of antibiotics), my RE didn't think much of it. The FET process can take a few tries even with a PGS tested embryo. Sounds like a beautiful a rainbow miracle! So weve been ttc for almost 2 years. Embryoman (Sean Lauber) is a former embryologist and creator of Remembryo.com. PGS testing (aka PGT-A) is a technique to help choose the best embryo for an embryo transfer. Im currently 17 weeks from another FET. Or they did but they were all aneuploid? I plan on asking my RE for a Recurrent loss panel to be done and autoimmune testing (NK cells etc)and a different protocol. (2016)found nostatistically significantdifference inongoing pregnanciesbetween Day 5 and 6 euploids (78.6% vs 67.4%), but this was reduced by Day 7 (43.8%). Im willing to try anything :) thanks for sharing! My lining a week before transfer was 6.8, but trilaminar lining was present. PGS can increase the rate of clinical pregnancy. He also answers questions in his private Facebook group. He suggested an endometrial biopsy instead. thats a great suggestion! I will talk to my dr about all of the above and hopefully i can finally get some answers :) My dr keeps pinning it on my lining but it doesnt make sense to me since Ive been over 8mm with a triple line pattern each chemical. And congratulations on your pregnancy!! We had PGS/PGD testing and an ERA. Euploid embryos are believed to have higher success rates and a reduced chance of miscarriage. Just trying to figure out what else I can do as I only have one embryo left. For women who have it, REs may suggest prednisone and lovenox after transfer. I am remaining hopeful, when we sent our embryos for testing, they only thought that one would come back normal. Success is still very possible, IVF treatments are often a trial and error situation as my doctor put it once. Wishing you lots of luck. So what if the embryos are euploid? I could tell that my dr thought we could just try again but she knew I needed to check something to feel ok with it. Trying to be strong and not make the holidays about my loss for the sake of my family, not sharing the news either until after. By 40 theres about a 1 in 4 chance of not getting a euploid and by 43 this doubles to half. So sorry this happened and good luck to you. Starting in the late 1990s, doctors testing fertilized eggs classified them as normal or abnormal, then added the classification "mosaic" in 2015. Maybe the wash too? ALL THREE DID!!! So crazy that its what finally worked. Have you been tested for APS (antiphosolipid syndrome)? Hi everyone. Id say if you feel you want the extra testing, push for it. I wanted to reach out and see if you know a way to find a surrogate on your own, rather than going thru an agency. (The embryo split!) Miscarriage of PGT tested embryo : r/IVF - Reddit How IVF with PGS is Changing the Fertility Game for Women over Age 35 This is exactly what I had! Thank you! PGS or Transfer 2 embryos? - Infertility - Inspire Thanks for sharing your story because it does give me hope! We are so happy about that, we just want this one to be the one. My current success was a FET with NO meds except vaginal progesterone. My RE had said shes usually very cautious when it comes to sending embryos out for PGS testing only because the process can sometimes compromise the embryo itself. Its very disheartening though. Any advice is greatly appreciated. Try to take extra good care of yourself while you regroup from this cycle, and then go with your instincts for your next cycle. 144 abnormal (aneuploid/mosaic) embryos and their outcomes. There isnt much data on it, and 2 of the 3 studies found no difference, so it isnt exactly clear. PGT-A miscarriage rates (euploid, mosaic, and aneuploid transfers) Thats a great suggestion, I will definitely ask my dr about doing an ERA. Why do euploid embryos miscarry? A case-control study - PubMed So all the aneuploid embryos that were transferred either didnt implant, or miscarried. More studies need to be done. Hi! What are the chances of having a miscarriage after transferring a PGT-A tested euploid embryo? In my case, my miscarriage was potentially caused by a partial uterine septate that my doctor identified via sonohystergram and removed via hysteroscopy. Wishing you the best of luck and baby dust. Also - wanted to add that I think my husband and I both did antibiotics still with our new clinic. This means that these women had euploid embryos for transfer. MENTS our next transfer was successful and I'm coming up on 12 weeks. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Chemical pregnancy with PGS-tested embryo - Ask the RE I did acupuncture that cycle. My doctor thought it was possibly due to retained products of conception. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. I will say that I have heard a LOT of stories of people having failures with PGS embryos followed by successes- on here and on instagram. I am new to the online support groups and considered joining months ago but struggled to even bring myself to put my story out there. In this post well learn more about IVF with PGS success rates for euploid embryos. We are currently waiting on the PGS results from the frozens from our third cycle. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. I cannot even imagine how it mustve been to go through all of that but Im happy to hear you finally got your miracle!!! I cried the whole way home. How Does PGS Testing Work? - Success Rate & Risks - Coastal Fertility We have our lining check on Friday. If you did PGS after multiple miscarriages and failed attempts how many did you transfer? However, that information will still be included in details such as numbers of replies. I can't tell if that is from the progesterone. I pay completely out of pocket for everything so the added expense was not something I wasnt looking forward to, but Im happy I went through with it. Obviously, when we look at transfer rates with PGS tested embryos, we are not including all the women who didnt have anything to transfer. Early Pregnancy Loss - Miscarriage Doctor in Los Angeles - USC Fertility About 7 months later I transferred a day 7. Hi all, I would Love and Need your opinions on this. Capalbo et al. I felt like a number in his practice, and I think he was milking my insurance for all he could get. Seems to work for many, many women. Why do we have to wait until we have a second devastating failure? This educational content is not medical or diagnostic advice. By screening out abnormal embryos with PGS, physicians can transfer just one chromosomally normal embryo, increasing the chances for having a successful singleton pregnancy and healthy child. I am thinking of you and truly wish you the best in January , Im sorry for a late response Ive been off the app to work on my mental health. I was put on the Schoyer protocol for stimulation. Fast Facts About PGS Testing Risks. However, theirsample sizewas small. Then another IVF/ICSI but nothing to transfer-- my doctor switched up my meds which was a bad idea obviously. Youre right! My AMH was low, around 1.5, FSH was slightly high, and follicle count was low normal. The ERA was about $800 and it took about 2 weeks to get the results. Thats definitely worth looking into, thanks for sharing your experience! Kelly. PGT-A is able to evaluate the % of cells that are abnormal in a biopsy sample and if theres a mix of euploid and aneuploid cells then the embryo is a mosaic. I also went for a lot of second opinionsall of the drs said there were many reasons and theories for why pgs embryos fail but its not uncommon. Your post will be hidden and deleted by moderators. Wondering if anyones had a similar experience or has any advice. (2016)looked at over 18,000 Day 5 embryo biopsies (usingthe older SNP technology) and reported the chances of an embryo beingeuploid(based on age): So up until 37 theres about a 50% chance of each blastocyst being a euploid, this cuts in half to about 25% at 42. I have expressed my concern but my RE believes it is more about the pattern. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Your story does give me hope and I wish my little one is as strong as yours! If your window is off I would think that could cause chemical pregnancies because the embryo would have a hard time implanting. Best of luck to you. Very frustrating to have an inconclusive. Patient(s): Cases included 38 patients who underwent frozen euploid ET as determined by aCGH, resulting in miscarriage. So I tried to find information through the site because I know topics like this have been posted before, BUT when I pull the results somehow PGS results in a whole lot of pregnancy posts as pg is used as a shortcut, and I am so all set with that. I paid a fortune for those sessions (I dont have insurance). Existing data show that the live birth rate is between 60-80% when a single frozen embryo is transferred in a second cycle. We did accupuncutre 2x a week prior to transfer and a pre/post on transfer day as well. Liebermann et al. My RE also encouraged us to just try another transfer rather than an ERA after our first chemical but then was on board after the second chemical happened. This study is considered the best quality evidence currently available for PGT-A (which showed no benefit over traditional grading for women <35 that you read about that here). Im hoping to do another transfer in January. Last January we found out we were pregnant but had a miscarriage at 7 weeks. It provides a greater scope of information to geneticists, it reveals mosaicism within the embryos, as well as minimising the risk of receiving false positive or negative results. At least testing a few variables like blood clotting. For <37, this was about 5, for 37-40 about 4, and for >40 about 3 (so older women tend to produce fewerblasts). In a small study,Bradley et al. My dr never mentioned anything regarding epigenetic issues. Pgs testing - how many normal? - Infertility - Inspire Im so confused as my RE says that morphology doesnt matter if theyre euploid. I needed additional days of progesterone and that was corrected for my 2nd FET. I am not naive I know bad things can happen. At the time, I was at rock bottom and going to an online support group. The usefulness comes when someone who is starting IVF and considering PGS testing. Because of my age and being diagnosed with diminished egg reserve we did "embryo batching" and I had 4 rounds of egg retrievals before moving onto any transfers. My questions is only 28% of our blastocysts passed pgs testing which is quite low from what is predicted for those under 35. Best of luck to you. I did do another round of IVF and am now 17 weeks pregnant. I'm glad we did - because my ERA results were abnormal and I needed 12 more hours of PIO. Did your RE have you take anything other than progesterone and estrogen and aspirin? For example, say a 39-year old woman has 3 embryos after her IVF cycle. I also had a chemical with a PGS tested embryo. 35 years old You can check out my summary of the study here. Please specify a reason for deleting this reply from the community. There is much better chance of IVF success with PGS testing in women who were over the age of 35. Once I started hearing other people's stories I was shocked at how common it is- more so than I ever would have imagined. So what gives now?? For women 35-40 years old, there was no statistical difference (8.2% for PGT-A vs 11.0% for untested). The protocol was exactly the same as with the chemical pregnancy with addition of baby aspirin. They biopsied those 2 embryos and send off the cells for PGS testing. When we started I was told by an RE I had a 2% chance of having a baby with my own eggs. Theper retrievalstatistic helps to see the chancesbefore PGStesting. It is seriously invaluable to me. Live birth rate differences are inconsistent and therefore inconclusive. Single embryo transfer both times. Please specify a reason for deleting this reply from the community. My first FET was a day 6 5AA euploid embryo. Im so sorry for your losses. Currently 8 weeks. What would they tell me and how would they impact protocol differently? You may want to ask/consider this before moving on for more data before trying with another precious embryo. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Consult with your doctor before making any treatment changes. Thanks! FAILED FIRST FET (Chemical Pregnancy). I have a Day 7/PGS Euploid I haven't done the transfer yet due to various reasons, and even though nothing is guaranteed, I like going into it knowing that I have a better chance because it is a normal embryo. I didnt realize you could transfer your embryos to another clinic. 4 PGT-M and PGT-A vs. Prenatal Testing Would love to hear if it was successful - fingers crossed . The good thing is she did not see any scar tissue during the biopsy, and the inflammation had completely cleared up. So mosaics can have a varying rates of miscarriage depending on the type of abnormality present. History Good luck and dont give up on hope yet! Zhao et al. Embryoman (Sean Lauber) is a former embryologist and creator of Remembryo.com. I'm curious if this might have something to do with it. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. She said that this is something that is prevalent in recurrent pregnancy loss and failed implantations. definitely worth asking! (2021) in their multicenter prospective trial transferred 484 euploid, 282 low mosaic (where 20-30% of the cells are aneuploid) and 131 moderate mosaic (30-50%) embryos. Disclaimer: Any studies presented here may be contradicted by other studies. I also am interested in doing an endo scratch beforehand and adding Viagra if the shots and scratch aren't doing the job. IVF/ICSI #3 another chemical with two frozen embryos left over. Only one normal PGS embryo - any advice on preparing for - Inspire I'm 37 years old, and I just had a chemical pregnancy with a PGS-tested embryo. I am so frustrated, disappointed, hurt, sad and angry right now. Why not do all the tests now and try to avoid another heartbreak? I feel like your doctor should have mentioned the ERA and biopsy by now.