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To differentiate between the different silica analogues, new CAS Registry numbers have been assigned. In the unlikely event that an active ingredient inadvertently reduces the melting point of the suppository base (especially solution suppositories), silica can be added to prevent this phenomenon. Colloids Surf B Biointerfaces 108:110119. Silica colloidal anhydrous (colloidal silicium dioxide) Practically insoluble in water, propylene glycol, glycerol, organic solvents, mineral oil, and most acids. Gluten-containing ingredients may be present or handled in the same manufacturing facilities and although strict clean-down procedures are adhered to in these GMP facilities, please be aware of this when deciding if Qsilica is right for you. No, all of our Qsilica products are 100% vegan and cruelty-free and therefore contain no animal ingredients. J Am Chem Soc 133:2044420457, Cauda V, Schlossbauer A, Bein T (2010) Bio-degradation study of colloidal mesoporous silica nanoparticles: effect of surface functionalization with organo-silanes and poly(ethylene glycol). The production process does not involve plant or animal based raw materials, nor does it involve organic solvents. The liquid can be added to smoothies or a water bottle for consumption throughout the day. Discuss essential solutions for the composite industry at JEC World 2023, My Nouryon - An online self-service portal for customers and distributors, Nouryon's World - Join our animated experience, 2023 Nouryon - Chamber of Commerce no: 81195664, Mitigating climate change and improving eco-efficiency, Our World of Essential and Sustainable Solutions. (2010) Highly PEGylated silica nanoparticles: ready to use stealth functional nanocarriers. Nails Hair and Skin - Blackmores Low pH versions of colloidal silica are also available by the adsorption of cationic aluminum oxide onto the surface of the particles. Convention, Food Chemicals Codex (11th Edition), (2018). ASP and MBC acknowledge UNLP and CONICET for their support. (2011) Photo-reversible supramolecular hyperbranched polymer based on hostguest interactions. https://doi.org/10.1016/j.micromeso.2010.11.013, Mosquera J, Garca I, Henriksen-Lacey M et al. It is advised to only take Qsilica products when they are in-date. Provided it is stored appropriately and as recommended, the material does not undergo any significant chemical changes, even after several decades. The SiO2 molecules in synthetic silicon dioxide do not exist in isolation. (PDF) On the mechanism of colloidal silica action to improve flow Chem Phys Lett 191:327335. (1990) Reduced thrombogenicity of polymers having phospholipid polar groups. Hoet, Opinion of the Scientific Committee on Consumer Safety (SCCS) Revision of the opinion on the safety of the use of Silica, Hydrated Silica, and Silica Surface Modified with Alkyl Silylates (nano form) in cosmetic products, regulatory toxicology and pharmacology, 74 (2016) 79-80. PLoS One 10:e0141593. ACS Sustain Chem Engeneering 5:48794889. John Wiley & Sons, Inc. Kosmulski M (2009) Compilation of PZC and IEP of sparingly soluble metal oxides and hydroxides from literature. In addition, the Qsilica ONE-A-DAY range also contains biotin, zinc and selenium for added skin, hair and nail health and protection against free radical damage. https://doi.org/10.1021/ja951550d, West R, Whatley LS, Lake KJ (1961) Hydrogen bonding studies. (2015) Nanoparticle colloidal stability in cell culture media and impact on cellular interactions. Precipitated silicon dioxide is silica produced in an aqueous solution at temperatures >60 C. Drug Development and Industrial Pharmacy 31 (2005) 687-696. Compared with traditional wet granulation, MADG does not involve the use of heat to dry granules and involves fewer process steps. Medium-shear mixers should be used for semisolid products. Any standard silica grade can be used, although grades with much larger specific surface areas, such as Evoniks AEROSIL 300 Pharma are the most recommended. Purity and reliability of raw materials are just two of the many challenges you face as a manufacturer of pharmaceutical products. A debate on whether Colloidal silica particles fall under the definition of nanomaterials has been ongoing for some time now, and a resolution does not appear to be imminent. J Colloid Interface Sci 33:430438. To maintain stability, purity and a safe shelf life . colloidal silicon dioxide anhydrous; crystallized silicon dioxide; e-551; fumed silicon dioxide; ins no.551; ins-551; light anhydrous silicic acid; light anhydrous silicic acid [jan] ludox; quartz; quartz [inci] quso f-22; quso f-22 [ii] rock crystal; sand; sand [inci] silica; silica [inci] silica aerogel; silica gel; silica gel [vandf] silica . https://doi.org/10.1039/C5NR09112H, Tayama M, Inose T, Yamauchi N et al. Evonik offers a broad portfolio of silica products for the pharmaceutical industry based on more than five decades of experience. Currently, Precipitated silica is produced in volumes that are up to x10 greater than for Pyrogen silica. Chem Rev 65:177198. Acta Biomater 84:317327. The pyrogenic method for producing Silica was invented in 1941 by Harry Klopfer, a scientist at Degussa (now part of Evonik AG). Microporous Mesoporous Mater 141:199206. It is not irritating to skin and eyes and passes through the gastrointestinal tract without being assimilated in detectable amounts. Small 6:17941805. Qsilica ONE-A-DAY is ideal for consumers looking for a higher-dose silica supplement plus the added antioxidant and skin support nutrients and is safe to consume on an on-going basis. Part Part Syst Charact 37:15. Theranostics 10:98659887. (2021) Curcumin-loaded mesoporous silica nanoparticles with dual-imaging and temperature control inhibits the infection of Zika virus. Snyder, F.A. It is recommended that concentrations of 0.5 to 2.0 % w/w be used in suppositories. https://doi.org/10.1038/nchem.1213, Garca KP, Zarschler K, Barbaro L et al. PDF AEROSIL and AEROPERL Pharma Colloidal Silicon Dioxide Products Shank, T.J. Slaga, P.W. . Part Fibre Toxicol 10:56. https://doi.org/10.1186/1743-8977-10-56, Docter D, Bantz C, Westmeier D et al. https://doi.org/10.1021/acs.chemmater.9b00221, Choi E, Lim D-K, Kim S (2020) Hydrolytic surface erosion of mesoporous silica nanoparticles for efficient intracellular delivery of cytochrome c. J Colloid Interface Sci 560:416425. J Inorg Biochem 69:177180. PDF SILICA, COLLOIDAL ANHYDROUS SILICA, COLLOIDAL HYDRATED - uspbpep.com Anhydrous colloidal silica (Aerosil 200, Evonik Corporation, USA) was used as glidant. The maximum weight fraction of silica in the dispersion is limited based on the average particle size. Colloidal anhydrous silica (silicon 70 mg) 150 mg Contains: If you are pregnant or breastfeeding, talk to your health professional before use. https://doi.org/10.1016/j.micromeso.2017.04.006, Prasetyanto EA, Bertucci A, Septiadi D et al. https://doi.org/10.1021/ja00053a020, Kresge CT, Leonowicz ME, Roth WJ et al. anhydrous colloidal silica content of the drug formulations. https://doi.org/10.1021/la201940r, Croissant JG, Fatieiev Y, Khashab NM (2017) Degradability and clearance of silicon, organosilica, silsesquioxane, silica mixed oxide, and mesoporous silica nanoparticles. https://doi.org/10.1016/j.biomaterials.2017.02.018, Article This is where our silica products come in: As flow aid, they ensure uniform active ingredient content in every tablet or capsule and increase production throughput. ACS Nano 6:58455857. A recommended starting level is 3 % w/w of Colloidal silicon dioxide, which can be adjusted up or down, depending on the viscosity desired. (1992) A new family of mesoporous molecular sieves prepared with liquid crystal templates. The sweet spot is 0.5% w/w, which can be adjusted up or down depending on the required performance (the range varies between 0.2 and 1.0% w/w). (2014) Fabrication of single-hole glutathione-responsive degradable hollow silica nanoparticles for drug delivery. This should be done with the most cohesive ingredient, if present. In standard coating processes involving powder layering, Colloidal silicon dioxide is used to facilitate powder build-up in the coating while also helping maintain pigments in suspension. https://doi.org/10.1002/chem.201601714, Fei W, Chen D, Tang H et al. J Colloid Interface Sci 33:420429. If more serious issues such as unusual hair loss or skin problems are the primary concerns, it is suggested that professional health care advice is sought - factors such as stress or hormonal imbalance may need to be considered. [12] Jonat, S., Hasenzahl, S., Gray, A., Schmidt, P. C. Influence of compacted hydrophobic and hydrophilic colloidal silicon dioxide on tableting properties of pharmaceutical excipients. The recommended concentrations of colloidal silica in transdermal drug delivery systems are generally between 1 and 5 % w/w. Chem Mater 31:5761. (2017) Degradation of core-shell Au@SiO 2 nanoparticles in biological media. What is it, harm, benefit, instructions for use Unlike other forms, colloidal silicon dioxide belongs to the hydroxyl group of substances. FAQ's - Qsilica Therefore, APIs must first undergo dissolution in gastric juices and successfully permeate the lipid membrane of the intestinal wall. Adv Funct Mater 30:1909539. https://doi.org/10.1002/adfm.201909539, Stber W, Fink A, Bohn E (1968) Controlled growth of monodisperse silica spheres in the micron size range. We recommend being consistent as well as following the directions for use on the label. The symptoms did not appear when valsartan in capsule form was prescribed. Break up any large agglomerates (which normally exist in many grades of silica) and mix the entire amount of Colloidal silicon dioxide with a small quantity of one of the other formulation ingredients. ACS Appl Nano Mater 3:1193311944. https://doi.org/10.1021/ac0693619, Nakamura M (2010) Approaches to the biofunctionalization of spherical silica nanomaterials. (2016) A comparison of techniques for size measurement of nanoparticles in cell culture medium. Colloidal silicon dioxide is an effective excipient for stabilizing dispersions of solids in liquids and preventing the formation of hard sediments in liquid suspensions and aerosol formulations intended for topical (rather than inhalation) use. When silica is being handled, electrostatic charging can occasionally occur, for example when the silica sack is being emptied. These colloidal silicas are commercially available in the form of sols or dried powders (e.g., xerogels, dry precipitates, aerogels, or calcinated coarcervates). TruQuality | Metagenics Of all the oxide minerals in the Earths crust, silicon dioxide, or silica, is the most abundant. https://doi.org/10.1002/jbm.820251107, Knowles BR, Wagner P, Maclaughlin S et al. Qsilica liquid should be stored below 25C before opened. (2015) Bimodal acidity at the amorphous silica/water interface. Pharmaceutical-approved hydrophobic silica is produced by reacting hydrophilic silicon dioxide with dimethylchlorosilane immediately after the production of Silica particles in the hydrogen flame chamber. Learn more about how to handle our products in a safe manner. (2020) Degradation of silica particles functionalised with essential oil components under simulated physiological conditions. M. Fuji, H. Iwata, T. Takei, T. Watanabe, M. Chikazawa, The change in the water vapor affinity of fine silica particles loaded with trimethylsilyl groups, Advanced Powder Technology, 8 (1997) 325-334, R.D.A. https://doi.org/10.1021/la8007206, Rio-Echevarria IM, Selvestrel F, Segat D et al. Usually they are suspended in an aqueous phase that is stabilized electrostatically. Langmuir 26:1688416889. https://doi.org/10.1016/j.cis.2009.08.003, Parks GA (1965) The isoelectric points of solid oxides, solid hydroxides, and aqueous hydroxo complex systems. Chem Commun 47:532534. (2019) Zwitterion functionalized silica nanoparticle coatings: the effect of particle size on protein, bacteria, and fungal spore adhesion. Naturally occurring in Quartz crystal, colloidal mineral silica (importantly, the element silicon contained within it) is the second most abundant element in the Earth's crust. Blending should not be for an extended period. Microporous Mesoporous Mater 282:243251. (2019) Dual GSH-exhausting sorafenib loaded manganese-silica nanodrugs for inducing the ferroptosis of hepatocellular carcinoma cells. Silica tetrahedra may be linked and arranged in a variety of ways, from simple to complex three-dimensional frameworks. They do not cause silicosis. Colloidal silica dispersions are fluid, low viscosity dispersions. If you are pregnant, considering becoming pregnant or breastfeeding, we recommend seeking professional health care advice from your practitioner prior to making any dietary changes such as incorporating a supplement into your routine. https://doi.org/10.1021/acs.chemmater.8b04647, Perdoor SS, Dubois F, Barbara A et al. [1] Evonik Industries, AEROSIL(R) Pharma Colloidal silicon dioxide, Technical information. https://doi.org/10.1021/j100812a002. Ion exchange. These dispersions are stable below a pH of 4. Adv Mater 33:2005215. https://doi.org/10.1002/adma.202005215, Li Z, Mu Y, Peng C et al. ACS Appl Mater Interfaces 9:1858418594. https://doi.org/10.1021/acs.chemmater.6b03896, Shen D, Yang J, Li X et al. Under Section 107 of the Copyright Act 1976, allowance is made for Fair Use for purposes such as criticism, comment, news, reporting, scholarship, education, and research. SAS is highly pure, crystalline-free, silicon dioxide, SiO2, which may be produced as pyrogenic (also called fumed) silica, precipitated silica and silica gel. PharmaCentral.com does not make any representation or warranty of any kind regarding its accuracy, adequacy, or legality. [13] Dal Zotto, M., Realdon, N., Ragazzi, E., Dalla Fini, G., Effects of two different kinds of silicon dioxide on release of drugs from suppositories: benzydamine hydrochloride. https://doi.org/10.1021/la500057j, Knop K, Hoogenboom R, Fischer D, Schubert US (2010) Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. J Non Cryst Solids 104:95106. It is also worth noting that the silica particles and aggregates are self-supporting and stabilised dispersions of silica particles in a continuous air phase and are unaffected by gravitational forces. J Colloid Interface Sci 133:105117. https://doi.org/10.1016/0079-6700(92)90023-R, Muller P (1994) Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994). https://doi.org/10.1182/blood.V55.1.156.156, Wang L, Wang K, Santra S et al. https://doi.org/10.1016/j.cis.2016.10.005, Currie EPK, Norde W, Cohen Stuart MAC (2003) Tethered polymer chains: surface chemistry and their impact on colloidal and surface properties. Nanoscale 12:1673816754. https://doi.org/10.1021/acs.langmuir.0c01545, Sun JT, Yu ZQ, Hong CY, Pan CY (2012) Biocompatible zwitterionic sulfobetaine copolymer-coated mesoporous silica nanoparticles for temperature-responsive drug release. The products are not to be mistaken as "colloidal silica" or "silica sol" which stands for dispersions of CRC Press, Taylor and Francis Group, LLC, Zou Y, Huang B, Cao L et al. These changes, while not necessarily affecting the silica content, density, refractive index, colour, or amorphous form, do impact three key parameters, i.e: As a result, different commercial grades of colloidal silicon dioxide, such as AEROSIL (Evonik), Cab-O-Sil (Cabot Corporation) and Wacker HDK (Wacker-Chemie GmbH) may differ in these parameters. Adv Funct Mater 29:1904216. https://doi.org/10.1002/adfm.201904216, Lee JE, Lee N, Kim T et al. https://doi.org/10.1021/cr60234a002, Kosmulski M (2016) Isoelectric points and points of zero charge of metal (hydr) oxides: 50 years after Parks review. https://doi.org/10.1016/j.cis.2017.10.005, Ratirotjanakul W, Suteewong T, Polpanich D, Tangboriboonrat P (2019) Amino acid as a biodegradation accelerator of mesoporous silica nanoparticles. However, as the different polymorphs of silica differ in their hazards to human health, it is essential, to distinguish carefully between crystalline silica and synthetic amorphous silica (crystalline-free). https://doi.org/10.1016/j.ijpharm.2008.05.003, Dong R, Liu Y, Zhou Y et al. A key advantage of Colloidal silicon dioxide is that only a small quantity is needed to improve the flowability and compressibility of a powdered formulation, which yields strong tablets and higher content uniformity. The role of silica is less obvious in animals, but each one of us contains about half a gram of silica without which our bones, hair, and teeth could not be formed. Langmuir 30:96259636. (2020) Highlights in mesoporous silica nanoparticles as a multifunctional controlled drug delivery nanoplatform for infectious diseases treatment. Thank you Surprisingly, when the sustainability of Colloidal silicon dioxide was assessed by the Excipients Forum, it achieved a score of 43 out of 100 on their Sustainable Chemistry scheme. Low pH grades can also be obtained by completely deionizing the dispersion.These grades do not require the presence of stabilizing ions and are also stable below a pH of 3. If the pH is reduced below 7 or if salt is added, then the units tend to fuse together in chains. Please note that we do not offer returns or refunds on change of mind purchases. (2015) Organic modification of hydroxylated nanoparticles: silica, sepiolite, and polysaccharides. https://doi.org/10.1016/0022-3093(88)90187-1, Liberman A, Mendez N, Trogler WC, Kummel AC (2014) Synthesis and surface functionalization of silica nanoparticles for nanomedicine. Colloidal silicon dioxide is currently approved by the FDA, is GRAS listed and included in the FDA Inactive Ingredients Database. https://doi.org/10.1016/j.colsurfb.2014.12.036, Knowles BR, Wagner P, Maclaughlin S et al. (2013) Preparation, purification, and characterization of aminopropyl-functionalized silica sol. Adv Colloid Interface Sci 152:1425. MORE, We are offering peanut-shaped, spherical and dry IDISIL Colloidal Silica grades in different particle sizes and with customized functionalization. In addition, it is approved for use in food, cosmetics and pharmaceutical applications. 7631-86-9. Whether you manufacture medicines for solid, semi-solid or liquid dosing, we support you at every stage of product development. Note that these silica grades can be used in their native (unprocessed) state. The method and conditions have been fine-tuned and now permit production of many types of synthetic silica that are structurally and characteristically different, including exhibiting internal pore volume/specific surface area, larger particle sizes, and water content. https://doi.org/10.1039/d0nr09220g, Marques MRC, Loebenberg R, Almukainzi M (2011) Simulated biological fluids with possible application in dissolution testing. https://doi.org/10.1246/bcsj.20150420, Lin Y, Abadeer N, Haynes CL (2011) Stability of small mesoporous silica nanoparticles in biological media. Langmuir 36:1144211449. The interplay between NPs aggregation and degradation has been scarcely explored in the literature when biological fluids are seriously taken into account. ACS Appl Mater Interfaces 12:117125. Bergfeld, D.V. J Am Chem Soc 133:25252534. Nanomedicine 6:715728. While liquids may be absorbed a little quicker, the disintegration of tablets or capsules is generally quite fast once the digestive process begins. Wiley Interdiscip Rev Nanomed Nanobiotechnol 13:123. A key feature of gels obtained with colloidal silica that makes them different from other types of gels (for instance, those obtained with hydrocolloid gums) is that their viscosities show little dependence on temperature. PDF Silicon Dioxide, Amorphous - Food and Agriculture Organization Langmuir 27:98239833. Academic Press, Bostrm M, Deniz V, Franks GV, Ninham BW (2006) Extended DLVO theory: electrostatic and non-electrostatic forces in oxide suspensions. Anhydrous Colloidal Silica Excipient | Uses, Suppliers, and Silica, independent of its form and method of preparation (including by-products), is found under CAS Nr. (2014) Biodegradable ethylene-bis(propyl)disulfide-based periodic mesoporous organosilica nanorods and nanospheres for efficient in-vitro drug delivery. The clinical picture was established within 3-4 weeks, and disappeared within 1-4 weeks after withdrawal of the tablets, but with a return of the hypertension within 3 weeks. These authors contributed equally: Andressa da Cruz Schneid, Lindomar Jose Calumby Albuquerque, Gabriela Borba Mondo, Laboratrio Nacional de Luz Sincrotron (LNLS), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), CEP 13083-970, Campinas, SP, Brasil, Andressa da Cruz Schneid,Lindomar Jose Calumby Albuquerque,Gabriela Borba Mondo&Mateus Borba Cardoso, Instituto de Qumica (IQ), Universidade Estadual de Campinas (UNICAMP), CEP 13083-970, Caixa Postal 6154, Campinas, SP, Brasil, Gabriela Borba Mondo&Mateus Borba Cardoso, Instituto de Investigaciones Fisicoqumicas Tericas y Aplicadas (INIFTA-UNLP-CONICET), 1900, La Plata, Argentina, You can also search for this author in Effect of colloidal silica on rheological properties of common - PubMed If the pH is kept slightly on the alkaline side of neutral, then the subunits stay separated, and they gradually grow. https://doi.org/10.1016/j.jcis.2019.06.044, Hu F, Chen K, Xu H, Gu H (2015) Functional short-chain zwitterion coated silica nanoparticles with antifouling property in protein solutions. https://doi.org/10.1016/0021-9797(89)90285-3, Sverjensky DA (2005) Prediction of surface charge on oxides in salt solutions: revisions for 1:1 (M+L-) electrolytes. Beilstein J Nanotechnol 5:13801392. It also provides pastes and ointments with the desired consistency and prevents separation of the various formulation ingredients, making it a highly versatile material with multiple pharmaceutical and cosmetic applications. SAS may sometimes be surface-treated to render it hydrophobic but these specialised products are produced at relatively low tonnage levels compared to the untreated material. Dispersions with a smaller average diameters have larger overall specific surface areas and are limited to low concentration dispersions. This is especially relevant for poor glass forming APIs, which can be difficult to stabilize with other formulation technologies. Suspensions of fine amorphous silica particles in a liquid, Learn how and when to remove this template message, It increase the bulk & taped density of powder & granules also, It is also be used in Lubrication of Tablet, https://en.wikipedia.org/w/index.php?title=Colloidal_silica&oldid=1136551695, Articles lacking sources from November 2021, Creative Commons Attribution-ShareAlike License 3.0, Stabilizing and rigidizing refractory ceramic fiber blankets, Liquid silicon dioxide (colloidal silica) is used as a wine and juice, This page was last edited on 30 January 2023, at 22:28. Products of this kind are also known as fumed silica in other industries. Nanomaterials 9:1365. https://doi.org/10.3390/nano9101365, Israelachvili J (2013) Intermolecular and surface forces, 3rd edn. It allows formulation ingredients to be uniformly distributed throughout the suppository base. After opening, it should be stored in the refrigerator at 2-8C with the cap tightly closed during storage.