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Common side effects of Prolia can vary depending on which condition the drug is being used to treat. And in my mind, that's no different than scheduling a visit to the dentist twice a year. Based on your dental history, your doctor can discuss with you the risks of using Prolia. No, weight gain wasnt reported as a side effect of Prolia in clinical trials. And some of these side effects are more common with certain uses of Prolia. Mild side effects can occur with Prolia use. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. This helps treat osteoporosis by improving bone mass and strengthening your bones. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.) * Symptoms can include: flushing (temporary warmth, redness, or deepening of skin color), swelling under your skin, typically in your lips, eyelids, feet, or hands, swelling of your mouth, tongue, or throat, which can make it hard to breathe. Kidney problems. Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. The lists below describe some of the more common side effects that Prolia may cause. Dietary calcium is considered safe, but too much calcium in the form of supplements might have some health risks. Tingling wasnt specifically reported as a side effect of Prolia in clinical trials. Sciatica is described as a shooting pain that travels from the lower back down a leg. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. Prolia is meant to be used in combination with calcium and vitamin D supplements. These can include tingling or numbness in the hands, feet, and face. Pay special attention to your dental hygiene. or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. Prolia (Injection) Uses, Dosage & Side Effects - Drugs.com Prolia is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture. Symptoms may include jaw pain or numbness, red or swollen gums, loose teeth, gum infection, or slow healing after dental work. Policy. Mild side effects of Prolia that have been reported include: Mild side effects of many drugs may go away within a few days or a few weeks. More than half of American adults take an herbal or dietary supplement, and many more use over-the-counter or prescription drugs to manage maladies ranging from the occasional headache to chronic health conditions or mood disorders.. For many, it is part of their daily routine. This makes your bones weak and increases your risk for bone fractures or breaks. If you have any questions about Prolias side effects, talk with your doctor. in your skin, lower stomach area (abdomen), bladder, or ear may happen. In rare cases, dental and jaw-related side effects have been reported with Prolia treatment. Use of the terms female and male in this article refers to sex assigned at birth. Before you start Prolia treatment, talk with your doctor about how long Prolias side effects may last. Scientists use genetic rewiring to increase lifespan of cells, Beyond amyloid and tau: New targets in developing dementia treatments, Napping longer than 30 minutes linked to higher risk of obesity and high blood pressure, Activity 'snacks' could lower blood sugar, complication risk in type 1 diabetes, In Conversation: Investigating the power of music for dementia, 11 ways to increase bone density naturally, 14 of the best calcium supplements in 2023. Prolia contains the same medicine as XGEVA (denosumab). For a basic overview of Prolia, including details about its uses, see this article. This medication guide provides information about the Prolia brand of denosumab. Your risk of bone fractures can increase when you stop, skip or delay using Prolia. Its recommended that calcium and vitamin D supplements be taken If your pain is more severe, your doctor may suggest prescription pain medication or physical therapy. You may have questions about Prolia and your treatment plan. Use of the term male in this article refers to sex assigned at birth. And if you have osteoporosis, falling could increase your risk of fractures. Do not stop, skip or delay taking Prolia without first talking with your doctor. WebYou should take calcium and vitamin D as your doctor tells you to while you receive The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. You should talk with your doctor if you develop any mild side effects that concern you. You should not breastfeed while using this medicine. It works with your immune system to help prevent bone loss. Some people have developed unusual fractures in their thigh bone. But hair loss has been reported by people who have taken Prolia since then. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. But some females* who received Prolia for osteoporosis after menopause had to stop Prolia treatment due to back pain. Starting an osteoporosis drug? Here Peripheral edema is a less common side effect that was reported in clinical studies of females* who received Prolia for osteoporosis after menopause. Get the treatment that fits your lifestyle, Stay informed with courtesy reminders, recipes and so much more. Problem absorbing minerals. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem. (2022). Calcium supplements may help support bone and teeth health. All rights reserved. And be sure to let your doctor know about all the medications youre currently taking. They might also recommend physical therapy, massage therapy, or using a heating pad. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. WebMost people can get adequate calcium through their diet if they make an effort. Women The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Discuss the foods you eat and the vitamins you take with your health care professional. Other drugs may interact with denosumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Specifically, Prolia is a monoclonal antibody (a lab-made protein). Prolia can also cause bones to not form correctly and reduced growth in a fetus. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. To help prevent low calcium, your healthcare provider may also This drug may not be the right treatment for your condition if you have certain medical conditions or other factors that affect your health. Tell your doctor right away if you become pregnant while taking Prolia. But if they become bothersome, talk with your doctor or pharmacist. to treat osteoporosis in males* and in females* whove gone through, to treat osteoporosis caused by long-term use of, metabolic bone disease, such as Hajdu-Cheney syndrome and juvenile. What should I know about Prolia vs. Zometa? More common side effects in females* who received Prolia for osteoporosis after menopause included: More common side effects in males* who received Prolia for osteoporosis included: More common side effects in people who received Prolia for osteoporosis due to drugs called glucocorticoids included: More common side effects in people who received Prolia to stop bone thinning due to certain cancer treatments included: For a complete list of all the side effects reported with Prolia, see the drugs prescribing information. Check with your doctor if you have more questions about these drugs. 2,4. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Version: 13.01. hydrochlorothiazide, alendronate, Fosamax, calcium carbonate, Premarin, Tymlos. Do not stop using this medicine without first talking to your doctor. Its possible that some of Prolias side effects may be long term, but theyre rare. Prolia also has other uses, which are described in the next section below. High cholesterol levels can be a side effect of Prolia. You may need to go to the hospital for treatment. Learn how to increase or maintain bone density here. Breastfeeding. We avoid using tertiary references. Vertigo (dizziness) was reported in some females* using Prolia for osteoporosis. Your doctor may also have you take certain supplements that contain calcium and vitamin D while youre receiving Prolia. Learn more about the unique risk factors for osteoporosis in, Osteoporosis weakens bones, which leads to breaks in the hips, wrists, and spine. You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or; if you are pregnant. Prolia is a prescription medicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments WebAdults ages 19 through 50 should not get more than 2,500 mg calcium total per day (including food and supplements). Theyll likely suggest other treatment options for your condition. Tell your doctor if youd like to know more about these drugs. This is because its not known if Prolia is safe to receive while breastfeeding. You do not give Prolia to yourself. Doing so will help to prevent dental problems. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments for prostate cancer that has not spread to other parts of the body. You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia. 2023 eHealthMe.com. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. 12 Low serum calcium levels should be corrected before starting denosumab; supplemental calcium and vitamin D is required in patients predisposed to hypocalcaemia (see Ensure adequate calcium and vitamin D intake ). Continue reading, Prolia is a prescription medicine injected under the skin (called a subcutaneous injection) and is given once every 6 months. Prolia: Side Effects, Alternatives, How It's Administered, Any advice? Additionally, in Prolia-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed. For instance: Both Prolia and Forteo are given as injections under your skin. Prolia injection is a brand of denosumab, which treats osteoporosis. Instead, your doctor may recommend that you make certain changes to your diet, such as increasing your calcium and vitamin D intake. (such as prednisone) for at least six months and are at high risk for fracture. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. These side effects may be temporary, lasting a few days or weeks. But weight gain may be a symptom of a side effect called peripheral edema. Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. Use effective birth control while using denosumab and for at least 5 months after your last dose. Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture These treatments may include acetaminophen (Tylenol) or ibuprofen (Advil, Motrin). These supplements help to prevent a low calcium level while youre taking Prolia. Bone density decreases with time, and some people have a risk of developing weak or brittle bones. Talk with them about your health and any concerns you have about Prolia and its effects. Do not become pregnant while taking this medicine or for 5 months after stopping it. Hair loss wasnt reported as a side effect during clinical trials of Prolia. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. They can tell you more about benefits and risks of Prolia and Forteo. But if youre planning to have surgery, you may need to take a break Both medications are approved to treat certain people with osteoporosis, as well as people with other conditions. Prolia can cause certain side effects, some of which are more common than others. You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. Doctors sometimes prescribe Prolia to treat osteoporosis and bone thinning. But Zometa contains the active drug zoledronic acid. If youre concerned about unexplained weight gain while using Prolia, talk with your doctor. You should not take Prolia if youve ever had an allergic reaction to Prolia or any of its ingredients. Call your doctor at once if you have a fever, chills, pain or burning when you urinate, severe stomach pain, cough, shortness of breath, skin problems, numbness or tingling, severe or unusual pain, or skin problems. Osteopenia For more information on this side effect, see Side effect specifics below. In addition to treating osteoporosis, which is described just above, Prolia also has other uses. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.). Nonmetastatic means the cancer hasnt spread to other areas of the body. Call your doctor for instructions if you miss a dose or miss an appointment for your Prolia injection. Like Helpful Hug REPLY 1 reply Mamie | @mamie | Oct Do not reuse a needle or syringe. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Prolia solution is available in one strength: 60 milligrams per milliliter (mg/mL). After you stop taking Prolia, youre more likely to experience bone loss, and your risk of a vertebral fracture increases. You may need to stop using the medicine for a short time. So, dont be afraid to ask questions or offer feedback on your treatment. But if you think youre having a medical emergency, call 911 or your local emergency number. Xgeva is used to treat a high calcium level due to cancer and to prevent bone fractures and other bone problems caused by multiple myeloma or cancer bone metastases. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). Your body needs calcium to build and maintain strong bones. Your heart, muscles and nerves also need calcium to function properly. Some studies suggest that calcium, along with vitamin D, may have benefits beyond bone health: perhaps protecting against cancer, diabetes and high blood pressure. Calcium has active ingredients of calcium. You may wonder how Prolia compares to the medication Zometa. Theyll also discuss with you how to lower your risk for fractures by adding other treatments or making certain lifestyle or diet choices. Copyright 2023 Elsevier Inc. All Rights Reserved. Medically reviewed by Sanjai Sinha, MD. While youre receiving Prolia treatment, your doctor will monitor your cholesterol levels with regular blood tests. Learn how to slow it down and fortify your body against it. With bone loss, your body loses old bone tissue faster than it makes new bone tissue. Although both drugs are approved to treat similar conditions, they work in different ways. MEDICATION GUIDE Prolia (PR-lee-a) (denosumab) Patients should not stop Prolia treatment without first consulting your This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. If youd like a detailed comparison of Prolia versus Boniva, view this article. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using Prolia. It may not cover all possible information. High cholesterol itself doesnt cause any symptoms. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply. Talk with your doctor about which medication is right for you. But if you think youre having a medical emergency, call 911 or your local emergency number. Yoga for Osteoporosis: 5 Beneficial Poses, Diet and Osteoporosis: Nutrients, Diet Tips, and More. But they each work differently because Prolia is a monoclonal antibody (it may also be called a miscellaneous bone resorption agent) and Reclast is a bisphosphonate which means they have different side effects, other uses, tolerability, and effectiveness profiles. Generic name: denosumab (Prolia) [den-OH-sue-mab] But Prolia is given once every 6 months by a healthcare professional. Every 6 months youll get another dose of Prolia. Prolia If youd like more information about Prolia use during pregnancy or while breastfeeding, talk with your doctor. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Find out which foods can help. Ask your doctor about your own risk. If you dont understand something related to your condition or treatment, ask your doctor to explain it to you. Prolia is a RANKL inhibitor. If your dizziness doesnt go away or becomes severe, talk with your doctor. You may take the carton out of the refrigerator and allow it to reach room temperature before the injection is given. Monoclonal antibodies are made to target and destroy only certain cells in the body. You can learn more about how we ensure our content is accurate and current by reading our. By stopping RANKL from binding to its receptor Prolia reduces bone breakdown, bone loss, bone pain, and other bone complications. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh. To learn more about this side effect, see Side effect specifics below. WebTake calcium and vitamin D as directed by your doctor, usually 1000 milligrams of calcium and at least 400 IU of vitamin D daily. It strengthens your bones by stopping certain bone cells called osteoclasts from breaking down your bones. For instance, if you have a health condition that causes excess calcium in Below are answers to some commonly asked questions about Prolia. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. According to the American Dental Association, your risk of this problem may increase if you receive denosumab (the active drug in Prolia) for longer than 2 years. Prolia is a prescriptionmedicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. Learn more about your health after menopause. It is often used in osteoporosis. Boniva contains the active drug ibandronate, but Prolia contains the active drug denosumab. Since different people They may want to check for other causes. Most side effects from Prolia are mild and can go away on their own within a few days or weeks. As mentioned above, Prolia contains the active drug denosumab. Prolia is a medicine that may affect the ability of your body to fight infections. You may wonder how Prolia compares with the alternative drug Reclast. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Denosumab Injection: MedlinePlus Drug Information Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. Your doctor can give you more information about the risks and benefits and how Reclast compares with Prolia. Prolia may not be right for you if you have certain medical conditions or other factors that affect your health. Prescribing Information and Our phase IV clinical studies alone cannot establish cause-effect relationship. Let your doctor know if you have questions about which drug is recommended for you. For more information about how these medications compare with each other, ask your doctor. Your risk for infection with Prolia may be higher if you have a weakened immune system. A severe jawbone problem called osteonecrosis has rarely been reported with Prolia. that's no different than scheduling a visit to the dentist twice a year. There are no known interactions with Prolia and other medications, supplements, or other products. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Call your doctor for medical advice about side effects. Visit your doctor or health care professional for regular checks on your progress. * Approximation only. Learn about the highest quality calcium supplements here. Other side effects may continue for as long as you receive the medication, but they can often be relieved with other treatments. Mild side effects that have been reported with Prolia include: These side effects may be temporary, lasting a few days or weeks. Your doctor can also help you decide if the benefits of Prolia treatment outweigh your risks of side effects. A biologic drug is made from parts of living organisms. Certain kidney problems, such as chronic kidney failure, can cause a low calcium level in your blood. But if your symptoms are serious and you think youre having a medical emergency, immediately call 911 or your local emergency number. If you cant properly absorb calcium or other minerals, be sure to talk with your doctor before using Prolia. (A placebo is a treatment with no active drug.). Osteoporosis Is Common in Older Men, Know the Risks, Your Guide to Osteoporosis and Broken Bones: Know Your Risks, 7 Things You Can Do Today to Prevent Osteoporosis, treat osteoporosis in males* and in females* whove gone through, treat osteoporosis caused by long-term use of, increase bone mass in females using certain, increase bone mass in males using certain treatments for, increased risk of bone fracture after stopping Prolia treatment, such as having multiple, severe pain in your joints, bones, and muscles, skin-related side effects, such as rash, dry skin, or blisters, decreased bone production, which means your bones take longer to make new bone tissue, dental problems and jaw-related side effects*, jaw necrosis (death of tissue in the jawbone), Prolias active ingredient is denosumab. Take good care of your teeth and gums while you receive Prolia. Prolia contains the active drug denosumab, while Fosamax contains the active drug alendronate. pain in bones and muscles, including back, arm, and leg pain, pain or swelling in the thigh or groin area. Prolia and Forteo are both used to treat osteoporosis. Common If your Prolia treatment is stopped, talk to your doctor about other medicine that They include bone pain, back pain, and a higher risk of certain infections. Not getting enough calcium in your diet can lead to fragile, brittle bones that are more prone to fractures and disease. They can help answer any questions you have about side effects from taking the drug. It is often used in osteoporosis. What should I know about Prolia vs. Boniva? Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Theyll discuss with you other treatments to help prevent bone loss. Whats the Connection Between Estrogen and Osteoporosis? They may give you tips on managing a body weight thats healthy for you. Calcium Prolia (denosumab) injection, for subcutaneous use. Your doctor may have you take extra calcium and vitamin D while you are being treated with Prolia. Prolia is sometimes used in people whose bone fracture is caused by certain medicines or cancer treatments. So be sure to talk with your doctor about any past or upcoming surgery before starting treatment with the drug. Its recommended that you take 400 international units of vitamin D and 1,000 milligrams (mg) of calcium with Prolia. Stopping Prolia doesnt cause withdrawal symptoms.