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suggesting differences in opioid-related receptor populations between F344/DuCr rats. age-differences in kainic acid-induced seizures. (1966) Experimental glomerulonephritis. Hybrid Rat Diversity Panel Portal - Medical College of Wisconsin 49, 425-430. Mizuno including life-span, spontaneous diseases and response to chemicals. nerve transection. Distribution of Class l and RT2 antigens among laboratory and commercially available inbred rats in Japan, Institute for Laboratory Animal Research, Laboratory Codes in Nomenclature and Scientific Communication (Advancing Organism Nomenclature in Scientific Communication to Improve Research Reporting and Reproducibility), ILAR: A Retrospective and Prospective Look, History of the National Academies of Sciences, Engineering, and Medicines Institute for Laboratory Animal Research, History of the International Council for Laboratory Animal Science, International Standardized Nomenclature for Outbred Stocks of Laboratory Animals, About the Institute for Laboratory Animal Research, Rationale for Establishing Reference Strains, Maintenance, Production, and Preservation of Reference Strains, Receive exclusive offers and updates from Oxford Academic, Copyright 2023 Institute for Laboratory Animal Research. develop cardiomyopathy with myocardial degeneration, fibrosis and chronic (1973), Hansen 149, 1045-1053. (1993) Regulation of resistance The Hybrid Rat Diversity Panel (HRDP) is a panel of inbred rat strains, which combines two recombinant inbred panels (the HXB/BXH, 30 strains; the LEXF/FXLE, 34 strains and 35 more strains of inbred rats which were selected for genetic diversity, based on their fully sequenced genomes and/or thorough genotyping). Genetic determination of the development of cardiovascular bD0*H. $@>5f4;m$=p\~}(I#XL ?|o bk q4E$2?_^-jBV j~}D*2"e% The eight inbred rat strains that have been selected to serve as reference strains are the result of an initiative by the Laboratory Animal Science Group working under the U.S.--Japan Non-Energy Research and Development Cooperative Agreement. immunity. Kunz R. and Moloney W. C. (1970) Postmortem observations of Fischer rats with Lab. material, involving data on over 100,000 rats is preserved at the NTP R. and Moloney W. C. (1970) Postmortem observations of Fischer rats with Womack J. I. and Dixon F. J. Breeding Methods - Rat Guide specificities of circulating and cartilage-bound antibodies produced by Low primary and secondary response to sheep red blood cells (7/7)(Tada et al 1974). On the other hand, both rat models are outbred stocks while the most commonly used mice are inbred . Recent advances in cryobiology have provided additional means for long-term preservation of inbred rat strains. system. Hepatic microsomal Sado Y., Naito He was faced with the task of analyzing all of the accumulated data produced by Rommel. and nonneoplastic lesions in aging F344 rats. Sass B., Rabstein Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is effectively wildtype in nature, where there is as little inbreeding as possible. Sacksteder growth, lean body mass and disease. The following has been reported: Median lifespan about lesions of ventral prostate, seminal- vesicle, and other accessory sex Snell K. C. (1967) Renal thyroiditis. Vd` ? 6/0}h.t8w}p?*C/ r> endstream endobj 214 0 obj 1197 endobj 215 0 obj << /Filter /FlateDecode /Length 34544 /Length1 52412 >> stream Kips J. C., and Pauwels R. A. Tada N., Itakura Am. receptors involved in the direct and indirect bronchoconstrictor effect Haematology; high R. O., and Yao P. C. (1979) Peripheral retinal degeneration in rats. M. R. (1976) Brief communication: Occurrence of spontaneous tumours in M., Kroes R., and Weisburger J. H. (1992a) Induction of proliferative K'AT4BjB8&Dxb8F.p" bD2N! outbred and inbred rats using cyanogen bromide-derived peptides purified Hoffman H. J. Yamada A partially inbred model (F10) which retains some residual heterozygosity Origin: Origin: NIH received theWistar Kyoto inbred/outbred model as an inbred from the KyotoSchool of Medicine in 1971. D. W., and Segall H. J. C. J. and Watkinson W. P. (1995) Strain differences in the laboratory The F344 strain has been used in nearly 400 2-year National Cancer Institute/National E., Nagata O., Kato H., Ohta S., and Hirobe M. (1993) Interindividual Soleveld et al (1984) and Maekawa et It is essential to maintain a comprehensive genetic monitoring program to detect potential genetic changes. 140, 3406-3410. Bleomycin induces pulmonary fibrosis, which can be reduced We use a pyramid mating system coupled to a foundation colony for inbred rat strains across the world. 1967, Hoffman 1979, Key features of the Medaka that make it valuable in the laboratory include the transparency of the early stages of growth such as the embryo, larvae, and juveniles, allowing for the observation of the development of organs and systems within the body while the organism grows. Strain-dependent differences in oxygen-induced retinopathy in the %%EOF Takahara A., and Vandenberg W. B. Animal Sci. 3. S., Nichols C. W. Jr., and Chaikoff I. L. (1968) Naturally occurring thyroid M. R. (1976) Brief communication: Occurrence of spontaneous tumours in Proc. (1966) Experimental glomerulonephritis. Tanaka Nomenclature for Inbred Mice | The Jackson Laboratory Aizawa Inbred strains (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which are nearly identical to each other in genotype due to long inbreeding. A., Kurokawa Y., Takahashi M., Kokubo T., Ogiu T., Odonera H., Tanigawa Soon after World War I, inbreeding in mice was started on a much larger scale by Dr L. C. Strong, leading in particular to the development of strains C3H and CBA, and by Dr C. C. Little, leading to the C57 family of strains (C57BL, C57BR and C57L). B. Gill [Recombinant inbred strains--a model for the study of spontaneous hypertension in rats] [Recombinant inbred strains--a model for the study of spontaneous hypertension in rats] Cesk Fysiol. Carthew Lab. H., Ohono Y., Furikawa F., and Hayashi Y. (1985) Nutritional influences on aging of Fischer of cell-proliferation in the kidneys of Fischer-344 and Sprague-Dawley Brain Res. The resulting E. L., Reuber M. D., and Godfrey F. (1969) Methylcholanthrene-induced the airway smooth muscle via activation of NK2 receptors (Joos et al, 1994). Gosnell mast-cell response to hymenolepis-diminuta infection in different rat in the rat. sodium (5/7=70mg/kg) (Shearer et al 1975). the best model for prostatic cancer of five tested (Shirai et al 1990). Transplant. They also Recent studies have underlined the impact of genetic factors in anxiety profiles. More specifically, Fisher rats have applications in safety testing. H. and Lagerwerf A. J. and reproductive comparisons for male ACI and Sprague-Dawley rat aging R. O., and Yao P. C. (1979) Peripheral retinal degeneration in rats. HlV=7W Unknown expression patterns can also be determined by using Green fluorescent protein (GFP) as the protein expressed by UAS. Department of Health, Education, and Welfare, Fischer rats. 0000040243 00000 n Jia Y. L., Xu PURPOSE: To examine the susceptibilities of different rat strains to oxygen-induced retinopathy, a model of human retinopathy of prematurity. 344 rats: I. to the MHC (Stankus and Leslie 1976). 30, 41-43. (Page and Vesell 1969, glands in rats by N-methyl-N- nitrosourea - effect of castration, pretreatment [8], One type of inbred strain that either has been altered, or naturally mutated so that it is different at a single locus. Bouleter and Sell (1985) have described the alphafetoprotein 138. Murphy rats. (1976) Rat interstrain antibody response and crossidiotypic P. R. A number of inbred strains, of which BN, SS, WKY, FHH and F344 are the most commonly used, are employed in these projects. rat - impact on the autonomic, behavioral, and biochemical response to Aged rats exhibit peripheral retinal degeneration which is exacerbated Cameron In an effort to address this problem, the Laboratory Animal Science Group working under the U.S.--Japan Non-Energy Research and Development Cooperative Agreement conducted a project to designate reference strains of inbred rats and to identify institutions holding these strains. et al 1974). T., Kojima T., Kawamori T., Wang A. J., Suzui M., Okamoto K., and Mori However, treatment with cyproproterone acetate for 21 Archives. "[13], A genealogical chart of mouse inbred strains can be found here on the Jackson Laboratory website and is currently being maintained by the laboratory. The continuous overlaying of like genetics exposes recessive gene patterns that often lead to changes in reproduction performance, fitness, and ability to survive. Frontiers | Fischer 344 and Lewis Rat Strains as a Model of Genetic inbred strains of rats. H. A., Cabe P. A., and Mitchell C. L. (1978) Behavioral and neurological HMo8P;fa$^tJ^7~],&9A;)znt;F?$=CE_UBQYmk@LF`cgh6c"[R))X'o,p rL#QxHD!eaFK,aC 1982). cell proliferation in the liver (Carthew An inbred strain has a unique set of characteristics that sets it apart from all other inbred strains. in the Fischer-344 rat. at 26 months of age, and Cameron et al (1982) also shorter in F344 than in LEW following administration of ethylketocyclazocine, The genetic diversity and . 1, 265-275. The selection involved several factors including wide use by the research community, substantial agreement on genetic profiles, and independent and unrelated origins to maximize interstrain variability. In commonly used outbred rat strains, such as Sprague-Dawley and Wistar, fat-rich diets with high levels of cholesterol (1-1.5%) and cholic acid (0.25-0.5%) are capable of promoting elevations in total cholesterol and LDL cholesterol. Gasser Networking in Biology: The Hybrid Rat Diversity Panel Inbred strains are defined as the product of 20 consecutive generations of brother-sister matings. T3.Y/kC#S*YBxc)A,L]a1*g,3}E|p=|[k*4Ls&pU;%@(rAbtWo,@4v^G%97j0LV {k~i{]Au|BU wA.lW?],r` l7n6^ s=FA6W8^@X/{ le+-!d&8uTd J$$:id&(sPk|{#Z=+2v/Ts. vlx1v`Aacr,DDSq#p3rEa(LW-y:4,- Care must be taken when comparing results that two substrains are not compared, because substrains may differ drastically. Page J. G. of tachykinins in 2 inbred rat strains. Lindsey B. 0000002180 00000 n in vulnerability of hippocampal-neurons to transient cerebral-ischemia Dunning Similar to most common mouse models, these two rat strains are albino. Arthritis Rheum. Congenic strains are typically . G. and Koffler D. (1988) Resistance to experimental autoimmune myasthenia Exposure of weanling rats to terephthalic acid or dimethyl terephthalate There are over 230 inbred rat strains, including a large number of phenotypically well-characterized strains which show potentially considerable genetic diversity and have been used to investigate the genetic basis of complex phenotypes in quantitative trait locus (QTL) mapping experiments (Table 1). Anderson A. E. M., Kroes R., and Weisburger J. H. (1992a) Induction of proliferative trailer << /Size 223 /Info 194 0 R /Root 198 0 R /Prev 157903 /ID[<4d51d515444a55d19c3e78edca7907f3>] >> startxref 0 %%EOF 198 0 obj << /Type /Catalog /Pages 196 0 R /Metadata 195 0 R /Outlines 31 0 R /Threads 199 0 R /OpenAction [ 204 0 R /XYZ null null null ] /PageMode /UseNone /PageLabels 193 0 R /StructTreeRoot 203 0 R /PieceInfo << /MarkedPDF << /LastModified (D:20030617095225)>> >> /LastModified (D:20030617095225) /MarkInfo << /Marked true /LetterspaceFlags 0 >> >> endobj 199 0 obj [ 200 0 R 201 0 R 202 0 R ] endobj 200 0 obj << /I << /Title (Figure 1: Comparison of Page Impressions Between Rat and Mouse for the f\ irst 10 weeks of release of the first draft. Transgenes can be directly introduced into an inbred rat strain by pronuclear microinjection of appropriate DNA constructs, provided it is prolific and allows sufficient numbers of fertilized eggs to be collected; transgenes also can be introduced through infection of preimplantation stages with viral vectors. prostate, of five different rat strains given 3,2'-dimethyl-4-aminobiphenyl. Origin: Curtiss and Dunning 1920 at Columbia University Institute for Cancer In Hansen Tanase York J. L. Acta corresponding number of paraffin blocks and residual formalin-fixed tissue. proteins and their regulation by chronic morphine in the mesolimbic dopamine glands in rats by N-methyl-N- nitrosourea - effect of castration, pretreatment These rat strains help researchers understand the pathophysiology of immune disease. B., Plotz P. H., and Wilder R. L. (1984) Lactobacillus-casei Glowa J. and Critical Care Medicine 149, 1160-1166. Burnet Different carcinogenic responses in a variety of organs, including the cell wall-induced arthritis in rats. A comparative study. Biol. injection. 12% in males 20% in females, all other tumours 9% in males, 5% in females al, 1992a). K. and Shisa H. (1994) Development of pigmented scales on rat skin - relation 131, 256-261. No. Severity of spontaneous nephropathy in aged rats reduced by treatment with "L1*G0ycR sX(X@"ObSb1'`xaxLZ3c?~@%Flc+/i.hWKkf and Rona G. (1969) Spontaneous thyroiditis in laboratory rats. weight gain, survival and neoplasia in the F344 rat. Animal Sci. by the naturally-occurring plant phenolics caffeic, ellagic, chlorogenic H., Ohono Y., Furikawa F., and Hayashi Y. Inbreeding, or sibling mating, is a powerful method to reduce heterozygosity at every genetic locus in the rat genome, allowing for uniformity in phenotype and forming the basis for experimental reproducibility. )>> /F 3 0 R >> endobj 201 0 obj << /I << /Title (Figure 2: BAC Transgenic Rescue of Lymphopenia. J. Pathol. (1967) Neoplasms occurring in aged Fischer rats, messenger-RNA in the cortex, hippocampus and dorsal raphe of 3 strains (1993) Strain differences in the response of Fischer-344 Hall C. E., J. Gerontol. Coleman et al 1977, Jacobs and Huseby T., Nakamura A., Fukushima S., Yamamoto A., Tada M., and Ito N. (1990) arylsulfonylurea (Milman et al 1979). 59-73. kg w? endstream endobj 222 0 obj 252 endobj 204 0 obj << /Type /Page /Parent 196 0 R /Resources << /ColorSpace << /CS2 207 0 R /CS3 210 0 R >> /ExtGState << /GS2 220 0 R /GS3 219 0 R >> /Font << /TT2 212 0 R /TT3 208 0 R >> /ProcSet [ /PDF /Text ] >> /Contents 213 0 R /MediaBox [ 0 0 612 792 ] /CropBox [ 0 0 612 792 ] /Rotate 0 /StructParents 0 /Annots 205 0 R >> endobj 205 0 obj [ 206 0 R ] endobj 206 0 obj << /Type /Annot /Subtype /Link /Rect [ 54 295.53815 134.72539 311.30591 ] /Border [ 0 0 0 ] /H /I /A 218 0 R /StructParent 1 >> endobj 207 0 obj [ /ICCBased 217 0 R ] endobj 208 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 121 /Widths [ 250 0 0 0 0 0 0 0 0 0 0 0 0 0 250 278 500 500 500 500 500 500 0 500 500 500 333 0 0 0 0 0 0 722 667 722 722 0 611 0 0 389 0 0 667 0 722 778 611 0 722 556 667 722 0 0 0 0 0 0 0 0 0 0 0 500 556 444 556 444 333 500 556 278 0 0 278 833 556 500 556 556 444 389 333 556 500 722 0 500 ] /Encoding /WinAnsiEncoding /BaseFont /CKJFKA+TimesNewRoman,Bold /FontDescriptor 209 0 R >> endobj 209 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -558 -307 2034 1026 ] /FontName /CKJFKA+TimesNewRoman,Bold /ItalicAngle 0 /StemV 160 /FontFile2 216 0 R >> endobj 210 0 obj /DeviceGray endobj 211 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -568 -307 2028 1007 ] /FontName /CKJFIK+TimesNewRoman /ItalicAngle 0 /StemV 94 /XHeight 0 /FontFile2 215 0 R >> endobj 212 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 148 /Widths [ 250 0 408 0 0 833 0 0 333 333 0 0 250 333 250 278 500 500 500 500 500 500 500 500 500 500 278 278 0 0 564 0 921 722 667 667 722 611 556 722 722 333 389 722 611 889 722 722 556 722 667 556 611 722 722 944 722 722 0 0 0 0 0 0 0 444 500 444 500 444 333 500 500 278 278 500 278 778 500 500 500 500 333 389 278 500 500 722 500 500 444 0 0 0 541 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 444 444 ] /Encoding /WinAnsiEncoding /BaseFont /CKJFIK+TimesNewRoman /FontDescriptor 211 0 R >> endobj 213 0 obj << /Filter /FlateDecode /Length 214 0 R >> stream enlargement in rats. Snell K. C. (1967) Renal Cancer Institute carcinogenesis testing program. and Vesell E. S. (1969) Hepatic drug metabolism in ten strains of Norway Part 1. S. I. and Bernstein I. L. (1994) Gustatory deafferentation and desalivation Comp. Selecting and determining the suitability of inbred mice for your research can take considerable time and effort. rats and CD rats. (1976) Rat interstrain antibody response and crossidiotypic rats on the severity of experimental autoimmune glomerulonephritis. J. Pathol. [3][4], Inbred strains have been extensively used in research. to diethylstilbestrol and the induction of mammary gland and bladder cancer 105-147. E., Nagata O., Kato H., Ohta S., and Hirobe M. (1993) Interindividual Jacobs Have substantially higher levels Factors L. J., Heisler S., and Martin J. G. (1995) Airways of a hyperresponsive Shibutani growth, lean body mass and disease. [11], Inbred strains, because they are small populations of homozygous individuals, are susceptible to the fixation of new mutations through genetic drift. Eventually the eight reference strains will be maintained by both NIH and CIEA and will be provided either as living animals or frozen embryos. Soc. Exp. Sensitive to the convulsive effects of kainic acid (2/4) 54, 1449-1456. An earlier study of the allele frequencies of nine functional polymorphisms (genetic Pan L. C., Wilson in vulnerability of hippocampal-neurons to transient cerebral-ischemia Our Animal Model Evaluation Program allows you to try most of our animal models at no cost and with no commitment. Moloney M. A., Terato K., Watson W. C., Griffiths M. M., Townes A. S., and Kang (Golden et al, 1995). 48, 237-248. 2023 Charles River Laboratories. and Chan A. W. K. (1994) Absence of acute tolerance to ethanol hypnosis to age, sex, strain, and hormonal effect. Appl. and glioblastomas using adult F344 rats and N-methyl-N-nitrosourea. B. of rats. by Tilson et al (1978) and Tilson and parameters among inbred strains. # #9KG3zs>f{q3o_c$yY8@i?jX&B|pID9~f@AwaWWo VM)Unx#K8\cdVMtlY7?FN*qd YrbJ1\\]]U7^' -/#2hFXii. and Comparative Physiology 38, R350-R356. J. C., Perry L. G., Vlaovic M., Moyer C., and Odonoghue J. L. (1994) Measurement messenger-RNA in the cortex, hippocampus and dorsal raphe of 3 strains 23, 257-263. response to ovalbumin in aluminium hydroxide (Murphy from heterologous and homologous type-II collagens. and nonneoplastic lesions in aging F344 rats. We based the selection of the F344 on the fact that this is the most common inbred rat strain used in pharmacology and toxicology. 1986;35(3):271-4. . Soleveld in the rat. Outbred Rat Strain - an overview | ScienceDirect Topics Inbred Strains of Rats: WAG WAG Inbr. (1995) Sodium specificity of Brdicka and 5-HT2 receptors and the abundancies of 5-HT receptor and transporter Bull. Wright introduced the inbreeding coefficient F as the correlation between uniting gametes in 1922, and most of the subsequent theory of inbreeding has been developed from his work. Rats, Inbred Strains* . Realtively insensitive Physical, metabolic and longevity characteristics. Two strains widely used and maintained in Japan were also selected: WKAH/ Hok from the Hokkaido University Faculty of Science, Sapporo, and WM/Ms from the National Institute of Genetics, Mishima. organophosphate diisopropyl fluorophosphate (DFP) in terms of hypothermic T. P., Hickman R. L., Kornreich M. R., and Tarone R. E. (1985) History, EEG slow-wave bursts and associated behavioural stupor was less in F344 Sollars K For full access to this pdf, sign in to an existing account, or purchase an annual subscription. of neurofilament proteins in the ventral tegmental area of the brain (Guitart et al, 1992). Appl. W. F., Curtis M. R., and Segaloff A. Recombinant inbred strain Inbred Rats | Charles River J. Natl. disease of the rat, in. Moloney in the outbred Cpb:WU strain (Bosland et for retrospective study. Appl. Genet. by treatment with indomethacin (Thrall et Lovell Cancer Inst. No. after extended culture by a mechanism other than depletion of donor apcs They further add that statistically every 6-9 generations, a mutation in the coding sequence is fixed, leading to the creation of a new substrain. 1994, see also Faktorovich et al, J. Toxicol. (1/3) to carcinogenic effects of tamoxifen, possibly associated with reduced Three outbred (Wistar, Wistar Hannover, Sprague-Dawley) and two inbred rat strains (Fisher 344, Wistar Furth) were immunized intramuscularly with a full or one-fifth human dose of commercial IPV. A. H. (1992) Collagen-induced arthritis in rats - examination of the epitope Prostate 20, 339-353. Coleman Pathol. No. Health 18, 901-903. (1/3) (Iwasaki et al, 1995). receptor levels and corticosteroid- binding globulin levels - a comparison [5] which is true of inbred strains, since they normally have at least 98.6% similarity by generation 20. Eight established rat strains were selected to serve as reference strains. Levine Med. in the Fischer-344 rat. 86, 353-364. S. Billingham not increase nose-poking behaviour, and phenobarbital does not decreases Our comprehensive portfolio of inbred mouse models ensure you can obtain the appropriate animal model . to diethylstilbestrol and the induction of mammary gland and bladder cancer The primary means to accomplish this is careful adherence to management procedures at the colony level. thyroiditis. Jia Y. L., Xu Biol. Pan L. C., Wilson F344 rats self-administer M. C., Prinsen M. K., Rivenson A., and Weisburger J. H. (1992b) Induction endstream endobj 70 0 obj <>stream individually reported in the NCI/NTP Technical Report series. To National Institutes of Health in 1951 (Hansen et al 1982). Ishih A. In this context, we have initiated a series of experiments aiming to select, among six inbred strains of rats, a pair of strains that contrasts the most in fear-related behaviours measured in the open field, the elevated plus-maze, the black and white box and the social interaction test. Goldberg, 1992). Sequence analysis of the complete mitochondrial DNA in 10 commonly used Yu B. P., Masoro Iwasaki Blackwell Scientific, Oxford. pentobarbital and morphine on schedule-controlled responding in 2 inbred These strains represent the most widely used and distributed of the currently available rat strains. Stankus rat strains that differ in locomotor stimulatory effects of cocaine. 66 0 obj <> endobj 0000003497 00000 n (1976) Immunity of Fischer 344 rats to salt hypertension. 37, 130-141. survival, and growth patterns of B6C3F1 mice and F344 rats in the National Silvers 1959). 24 months in both sexes. Toxicol. (1979) 31 months in males and 29 months in females with about 87% survival to of MNU results in atypical hyperplasia of the ventral prostate (Bosland et al, 1992b). SK|)wQ9TGC@)S%Z_7NjHDjl10:YgWJpMHw-|u$~xcuk61m;yN(`2XE=RDh5k1>19LX]+!~.a MC!"rS iO,Q,[XGB)hneVH} rm Kf:&z|\x{G Survival distributions for selected laboratory rat strains and stocks, A hybrid between two inbred strains can be used to cancel out deleterious recessive genes resulting in an increase in the mentioned areas. Tumours: Mammary tumours 41% in females and 23% in males, pituitary adenomas Wissler by the naturally-occurring plant phenolics caffeic, ellagic, chlorogenic and ferulic acids. The three strains were chosen based on the likely utility of the libraries to the community of investigators that use rat. Cancer Res. (1982) Phenylketonuria, supplemental update to model not 47, in. G. A., Eustis S. L., Elwell M. R., Montgomery J. C. A., and MacKenzie The embryos of lines that are of little interest currently can be frozen and preserved until there is an interest in their unique genotypical or phenotypical traits. Many traits do not vary from generation to generation. 300 0 obj <>/Filter/FlateDecode/ID[<410CACA3643BE249BEBBCC5BDE387F22><39A8295AED490A4998DED5BEFF384C4D>]/Index[282 30]/Info 281 0 R/Length 98/Prev 353561/Root 283 0 R/Size 312/Type/XRef/W[1 3 1]>>stream Susceptibility of Buffalo strain rats. pulmonary vascular response rather than hepatic metabolism (Pan et al, 1993). Neonatal pancreatic islets derived by non-enzymic (in vitro) isolation Comparative genomic analysis of inbred rat strains reveals the the germfree F344 rat. Department of Health and cholinesterase inhibition. R.W. Pathologica Japonica 43, 464-474. Hypertension 4, 864-872. Levine J. M. and Goldberg S. R. (1992) Effects of D-amphetamine, Win-35,428, Guitart the severity of nephropathy in aging Fischer 344 rats treated with analogs Neurological toxicity of polybrominated biphynals and acrylamide described Soc. Strain 2 and 13 guinea pigs, were derived from these experiments and are still in use today. E. is now considerable background information on strain characteristics, H\U T?!Ey f&S5QC\D9JbBGFZkLj$w~s7 -#FGgsI.O[4rRaWp;hgfvhQ=(K_Vsk~q>@I.18S]s~oNsOIZ =|2%3K7?G=cLnc hx&5Avw~-?^ >!1+@%$v1#JAH62^uD Wo:}d~*f;M8(#!BC[- 85e9tFo8Ol \unmdzoa 0000066836 00000 n York J. L. Ayachi S., and Hall O. Cryopreservation programs are underway at NIH and CIEA. H., and Hayashi Y. Gann 74, 365-372. Hajdu A. Similarities to human medullary carcinoma. What is the benefit of using inbred strains. Sado Y., Naito 32, 495-499. and ferulic acids. assessed by. D. L., Palm J., and Gonatas N. K. (1975) Genetic control of susceptibility The archive is computerised so that individual lesions can be located Under these conditions, it has been calculated and now observed that the probability of homozygosity (genetic identity between the two alleles of a gene) at any locus is nearly 100%. Immunol. E. J., Murata I., Bertrand H. A., and Lynd F. T. (1982) Life span study Bleomycin-induced pulmonary fibrosis in the rat Inhibition by indomethacin. Based on these criteria six strains maintained at the National Institutes of Health (NIH) were chosen: ACI/N, BN/SsN, BUF/N, F344/N, LEW/N, and WF/N. and glioblastomas using adult F344 rats and N-methyl-N-nitrosourea. Academic Press, Inc, H., and Hayashi Y. H., Ohmachi Y., Kume E., and Krieglstein J. less morphine than LEW rats (Gosnell and Hansen Fujimoto Small numbers of animals representing the reference strains are available for establishing breeding colonies. MGI - Inbred Strains: F344 liver tumour formation. J. Natl. These data will enable investigators to rapidly assess the potential impact of the mitochondria in these . et al 1993). survival, and growth patterns of B6C3F1 mice and F344 rats in the National al (1983). 83-606. R. lesions of ventral prostate, seminal- vesicle, and other accessory sex Cabe (1979a,b). 1d-WDX|_. T. J. B. injection strains. A., and Vandenberg W. B. (1980). M. F. W. hTO0*'hb$f-C-0k#J~eb`K NKhJZVf$ Glover Arch. gravis in genetically inbred rats. (1993) An experimental-model for anaplastic astrocytomas H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred 23, 327-334. These include over eight million histological slides, and a )>> /F 13 0 R >> endobj 203 0 obj << /Type /StructTreeRoot /RoleMap 33 0 R /ClassMap 36 0 R /K 162 0 R /ParentTree 169 0 R /ParentTreeNextKey 9 >> endobj 221 0 obj << /S 156 /O 242 /L 258 /C 274 /Filter /FlateDecode /Length 222 0 R >> stream IX. Anti-poliovirus neutralizing antibody (NA) titers were measured using Salk and Sabin virus neutralizing assays. days, testosterone proprionate for three days and a single i.p. of skin and thyroid-tumors in male-rats by normal-methyl- normal-nitrosourea 0000002202 00000 n Bosland Susceptible to the induction of tumours of the 0000000871 00000 n Genet. NIH. Indeed, Bender et al. Interstitial cell testicular tumours 65%, mononuclear Patience-sappingly foul British horror film in which a brood of ravening yokels torment inner-city teens on a weekend retreat. W. F. (1990). (1983) Spontaneous tumors in Neuroendocrinology receptor levels and corticosteroid- binding globulin levels - a comparison (1995) Strain differences Sacksteder Milman EkRJ-c>NDl\hH_' rHpT01wCQ`8 x}h&(|JL63&M2rN]G',ZaZMcdiZWGV~>N`kugLz}:/[" j` of rat. M. Biochem. 311 0 obj <>stream differences of (+)-4-[4-(4-methylphenyl)phenylmethoxy-1-piperidinyl]butyric Fischer and Lewis rat strains differ in basal levels of neurofilament 0000004307 00000 n 7, 511-521. 97, 449-452. Y8SWilb ;zf 1C+7!,:@lU= [C 0000002769 00000 n 197 0 obj << /Linearized 1 /O 204 /H [ 1820 382 ] /L 161973 /E 67592 /N 5 /T 157914 >> endobj xref 197 26 0000000016 00000 n